Author

Kyle Smith

Washington University in St. LouisORCID 0000-0003-3322-1793Unclaimed ORCID profile · follow to get notified of new preprints

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Kyle Smith4 papers · St. Jude Children's Research Hospital

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Emily WagneriD· 1 shared Erica MarqueziD· 1 shared Heather L. StruckmaniD· 1 shared Janice M. Amsler· 1 shared Jennifer NA Silva· 1 shared Jonathan D. MorenoiD· 1 shared Jonathan R. SilvaiD· 1 shared Joshua D JosefiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Emily WagnerORCID

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1 paper

Recent·Most cited

PhysiologyThe Journal of Precision Medicine Health and DiseasePeer-reviewedMar 19, 2026

Common Genetic Variants of The Cardiac Sodium Channel Alter Patient Response to Class 1b Antiarrhythmics

Martina Marras, Joshua D Josef, Thomas Schuster…·Jonathan R. Silva

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

DOI 10.1016/j.premed.2026.100034

humanelectrophysiology

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