Author

Heather L. Struckman

Washington University in St. LouisORCID 0000-0002-1758-0780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1

Frequent Co-Authors

Jonathan R. SilvaiD· 3 shared Erica MarqueziD· 2 shared Martina MarrasiD· 2 shared Nathaniel HuebschiD· 2 shared Thomas Schuster· 2 shared Abdul WasimiD· 1 shared Anastasia Khokhlova· 1 shared Anirban DasiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

Jonathan R. SilvaORCID

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Author profile →

4 papers

Recent·Most cited

Stress Granule Coarsening Is a Pathological Inflection Point for Cardiac Electrophysiological Dysfunction

Heather L. Struckman, Isabelle S. Field, Anna Z Li, Erica Marquez, Martina Marras, Thomas Schuster, Caroline Chou, Samantha Giangrasso, Kory J. Lavine, Dzmitry Matsiukevich, David M. Ornitz, Nathaniel Huebsch, Anastasia Khokhlova, Jonathan R. Silva

The paper identifies stress granule coarsening as a critical factor in cardiac electrophysiological dysfunction under oxidative stress.

bioRxiv · Jun 22, 2026 · PreprintBioengineering

Common Genetic Variants of The Cardiac Sodium Channel Alter Patient Response to Class 1b Antiarrhythmics

Martina Marras, Joshua D Josef, Thomas Schuster, Heather L. Struckman, Emily Wagner, Lucas Lee, Kyle Smith, Janice M. Amsler, Lucy S. Woodbury, Erica Marquez, Nathaniel Huebsch, Jonathan D. Moreno, Jennifer NA Silva, Jonathan R. Silva

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

The Journal of Precision Medicine Health and Disease · Mar 19, 2026Peer-reviewedPhysiology

Enantiomeric histidine-rich peptide coacervates enhance antigen delivery to T cells

Ushasi Pramanik, Anirban Das, Elise M. Brown, Heather L. Struckman, Huihao Wang, Samuel T. Stealey, Macy L. Sprunger, Abdul Wasim, Jonathan L. Fascetti, Jagannath Mondal, Jonathan R. Silva, Silviya P. Zustiak, Meredith E. Jackrel, Jai S. Rudra

This paper shows that enantiomeric histidine-rich peptides form coacervates that enhance antigen delivery to T cells, improving immune response.

Chemical Science · Jan 1, 2025Peer-reviewedBioengineering

Indirect Correlative Light and Electron Microscopy (iCLEM): A Novel Pipeline for Multiscale Quantification of Structure from Molecules to Organs

Heather L. Struckman, Nicolae Moise, Bieke Vanslembrouck, Nathan Rothacker, Zhenhui Chen, Jolanda van Hengel, Seth H. Weinberg, Rengasayee Veeraraghavan

The paper introduces iCLEM, a pipeline that correlates multiscale structural data from different imaging modalities using intrinsic fiducials, enabling structure-function relationship discovery.

Microscopy and Microanalysis · Feb 29, 2024Peer-reviewedSystems Biology