Author

Jonathan D. Moreno

Washington University in St. LouisORCID 0000-0001-5378-0192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Jonathan R. SilvaiD· 2 shared Joseph L. RansdelliD· 2 shared Druv BhagavaniD· 1 shared Emily WagneriD· 1 shared Erica MarqueziD· 1 shared Heather L. StruckmaniD· 1 shared Janice M. Amsler· 1 shared Jeanne M. NerbonneiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Jonathan R. SilvaORCID

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Author profile →

3 papers

Recent·Most cited

Common Genetic Variants of The Cardiac Sodium Channel Alter Patient Response to Class 1b Antiarrhythmics

Martina Marras, Joshua D Josef, Thomas Schuster, Heather L. Struckman, Emily Wagner, Lucas Lee, Kyle Smith, Janice M. Amsler, Lucy S. Woodbury, Erica Marquez, Nathaniel Huebsch, Jonathan D. Moreno, Jennifer NA Silva, Jonathan R. Silva

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

The Journal of Precision Medicine Health and Disease · Mar 19, 2026Peer-reviewedPhysiology

A reinterpretation of the relationship between persistent and resurgent sodium currents

Samuel P. Brown, Ryan J. Lawson, Jonathan D. Moreno, Joseph L. Ransdell

The paper investigates the role of resurgent (INaR) and persistent (INaP) sodium currents in regulating repetitive firing in Purkinje neurons, finding that INaP, not INaR, is critical for firing rate control.

Journal of Neuroscience · Jun 10, 2024Peer-reviewedNeuroscience

Intrinsic Mechanisms in the Gating of Resurgent Na+ Currents

Joseph L. Ransdell, Jonathan D. Moreno, Druv Bhagavan, Jonathan R. Silva, Jeanne M. Nerbonne

The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.

eLife · Jan 25, 2022Peer-reviewedNeuroscience