Jonathan R. Silva

The paper identifies stress granule coarsening as a critical factor in cardiac electrophysiological dysfunction under oxidative stress.

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

This study investigates how calcium regulates Nav1.5 inactivation through interactions with CaM and FGF12A, showing a Ca2+-dependent shift in steady-state inactivation.

This study investigates the functional role of the I-II linker in Nav1.5 channels, finding that a point mutation significantly affects channel gating while deletions have minimal impact.

This study investigates how FGF12A regulates Nav1.5 channel gating through CaM-dependent and CaM-independent mechanisms, revealing distinct effects on inactivation and persistent late current.

This paper shows that enantiomeric histidine-rich peptides form coacervates that enhance antigen delivery to T cells, improving immune response.

The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.