Philip K. Maini

Habitat degradation destabilizes complex metacommunities by disrupting dispersal

This study shows habitat degradation shifts metacommunities from stable to unstable regimes, increasing extinction risk, and highlights dispersal's role in stabilizing ecosystems.

RecA structure kinetics determine SOS dynamics and predict spontaneous cell death

The paper shows RecA* structure dynamics predict spontaneous cell death in E. coli by linking SOS response magnitude to DNA repair kinetics.

Impact of oxygen fluctuation and consumption on the dynamics of a reduced go-or-grow model for tumor cell invasion

This study shows that rapid oxygen fluctuations alter tumor growth dynamics in a go-or-grow model, with the full model outperforming a reduced version under these conditions.

Traveling Wave Analysis of a Go-or-Grow Invasion Model with ECM-Regulated Phenotypic Switching

The paper analyzes a go-or-grow invasion model with ECM-regulated phenotypic switching, showing that the reduced model captures the dynamics and deriving the minimum traveling wave speed.

Tipping Points and Emergent Phases of Species Diversity in Mutualistic Ecological Networks under Global Warming

This study identifies climate-induced tipping points in mutualistic ecological networks under global warming, showing three phases of species diversity and the impact of warming rate on ecosystem resilience.

Growth rate-driven modelling suggests that phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma

The paper develops a model to show phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma and suggests intermittent treatments may be more effective.

Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment

This paper develops a multiscale model to study how cell-ECM interactions affect ECM fibre alignment and cell detachment through mechanical cues.

Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model

This paper develops a stochastic model to assess the identifiability of phenotypic adaptation parameters from low-cell-count experiments and shows that cell-to-cell heterogeneity is non-identifiable from population-level data.

Predicting Treatment Outcomes from Adaptive Therapy -- A New Mathematical Biomarker

This paper develops mathematical biomarkers to predict treatment outcomes for adaptive therapy in cancer, showing personalized strategies outperform standard-of-care protocols.

Mathematical modelling predicts novel mechanisms of stream confinement from Trail/Colec12/Dan in the collective migration of cranial neural crest cells

The paper uses an agent-based model to simulate how Trail, Colec12, and Dan confine cranial neural crest cells to stereotypical migration pathways in vivo.

A new mechanochemical vertex model with Ca2+ signalling, for apical constriction in neural tube closure

The paper develops two new mechanochemical vertex models of apical constriction during neural tube closure, incorporating Ca2+ signalling and mechanical interactions to better align with experimental observations.

Characterising cancer cell responses to cyclic hypoxia using mathematical modelling

This study develops a mathematical model to simulate cancer cell responses to cyclic hypoxia and shows varying cell responses based on oxygen fluctuation dynamics.

When is spontaneous formation of spatial patterns robust?

This paper defines robustness for spatial pattern formation using random matrix theory and shows that advection, chemotaxis, and non-local interactions robustly generate patterns, while diffusion alone cannot.

Gap junctions in Turing-type periodic feather pattern formation

The paper investigates the role of gap junctions in Turing-type feather pattern formation using chicken skin and computational models.

Enhanced perfusion following exposure to radiotherapy: a theoretical investigation

This paper identifies vascular features that enhance perfusion after radiotherapy and develops a computational model to explore their impact on tumour response.

Turing pattern formation in reaction-cross-diffusion systems with a bilayer geometry

The paper analyzes Turing pattern formation in reaction-cross-diffusion systems with bilayer geometry, showing how coupling between layers can trigger or stabilize patterns.

A multiscale model of complex endothelial cell dynamics in early angiogenesis

This paper introduces a multiscale model of angiogenesis that reproduces vascular network features through cell rearrangements and uses a mixing measure to quantify cell mixing as a potential biomarker for pathological angiogenesis.

Neural crest cells bulldoze through the microenvironment using Aquaporin-1 to stabilize filopodia

The paper investigates the role of Aquaporin-1 in neural crest cell migration, finding it affects speed, direction, and filopodia stability through interactions with MMPs and pFAK.

Head Mesoderm Tissue Growth, Dynamics and Neural Crest Cell Migration

The paper investigates dynamic feedback between tissue growth and neural crest cell migration during chick head morphogenesis using time-lapse imaging, modeling, and perturbations, revealing its role in robust craniofacial development.

Chronic inflammation delays cell migration to villi in the intestinal epithelium

This study investigates how acute and chronic inflammatory cell death affects epithelial cell migration in the intestinal villi using computational models and cell-tracking methods.

Mathematical modelling of cortical neurogenesis reveals that the founder population does not necessarily scale with neuronal output

The paper develops a mathematical model of cortical neurogenesis to show that neuronal output can increase without a proportional increase in the founder population size.

Semblance Of Heterogeneity In Collective Cell Migration

The paper shows how cell populations can appear heterogeneous in migration despite identical individual behavior, highlighting statistical pitfalls in analyzing heterogeneity.

A hierarchical Bayesian framework for understanding the spatiotemporal dynamics of the intestinal epithelium

The paper develops a hierarchical Bayesian framework to model spatiotemporal dynamics of intestinal epithelium proliferation and migration under different conditions, concluding a proliferation-driven model is sufficient for most time-scales.

Microvessel Chaste: An Open Library for Spatial Modelling of Vascularized Tissues

Microvessel Chaste provides an open-source library for building and simulating 3D spatial models of vascularized tissue growth, integrating with experimental data and Python tools.