Author

Richard Y. Ebright

Broad InstituteORCID 0000-0001-8975-5810Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan G. Zhang· 1 shared Andrew E. H. EliaiD· 1 shared Andrew J. AguirreiD· 1 shared Arianny AcostaiD· 1 shared Aurelia Dingley· 1 shared Ben K. Wesley· 1 shared Ben S. WittneriD· 1 shared Cem TanrıöveriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alan G. Zhang

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2 papers

Recent·Most cited

Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer

Richard Y. Ebright, Yao He, Alan G. Zhang, Ian C. McCabe, Chinmaya U. Joisa, Tanay Thakar, Jayu Jen, Dennie Tompers Frederick, Arianny Acosta, Guangyan Li, Elena Kuehner, Vivian Yang, Katherine E Doherty, Natnael Yaregal, Ngan N. K. Van, , William R. Sellers

The paper identifies combinatorial KRAS/FGFR dependence in pancreatic cancer through genetic interaction mapping and shows that combined inhibition overcomes resistance.

bioRxiv · Sep 25, 2026 · PreprintCancer Biology

The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis

Joanna A. Vuille, Cem Tanrıöver, Ezgi Antmen, Douglas Scott Micalizzi, Richard Y. Ebright, Sambhavi Animesh, Robert Tyler Morris, Soroush Hajizadeh, Zachary J. Nicholson, Hunter C. Russell, Eric F. Zaniewski, Ben S. Wittner, Ben K. Wesley, Ji Eun Kwak, Julian Grünewald, , Daniel A. Haber

The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedCancer Biology