Author

Nicholas Luke Cowie

Novo Nordisk FoundationORCID 0000-0003-3367-2105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Lars Keld NielseniD· 3 shared Hooman HefziiD· 2 shared Igor Marín de MasiD· 2 shared Nathan E. LewisiD· 2 shared Alberte Sloth CarlseniD· 1 shared Alejandro Gómez ToledoiD· 1 shared Ana María Vega-LetteriD· 1 shared Anders Holmgaard HanseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersSystems Biology

Lars Keld NielsenORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintAug 10, 2026

Improved Metabolic Flux Estimations through Compositional Data Analysis

Alberte Sloth Carlsen, Te Chen, Nicholas Luke Cowie…·Lars Keld Nielsen

This paper improves metabolic flux estimation by applying compositional data analysis to isotopic metabolic flux analysis, reducing mean squared error and narrowing confidence intervals.

DOI 10.64898/2026.08.07.742769

metabolomicsstatistical model

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Systems BiologybioRxivPreprintApr 10, 2025

A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells

Pablo Di Giusto, Dong‐Hyuk Choi, Athanasios Antonakoudis…·Nathan E. Lewis

The paper presents iCHO3K, a comprehensive metabolic model of Chinese Hamster cells, and uses it to analyze metabolic changes in lactate-free cells, identifying structural insights into metabolic rewiring.

3 citations

mousemetabolomics

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BioengineeringNature MetabolismPeer-reviewedJan 14, 2025

Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells

Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas…·Nathan E. Lewis

This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.

28 citationstop 2%

mousehuman

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