Author

Anders Holmgaard Hansen

Novo Nordisk FoundationORCID 0000-0002-6007-4787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Nathan E. LewisiD· 4 shared Bjørn Gunnar Rude VoldborgiD· 3 shared Johnny ArnsdorfiD· 3 shared Sanne SchoffeleniD· 3 shared Austin W.T. ChiangiD· 2 shared Gyun Min LeeiD· 2 shared Haining LiiD· 2 shared Helene Faustrup KildegaardiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBioengineering

Nathan E. LewisORCID

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Author profile →

4 papers

Recent·Most cited

LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling

Haining Li, Angelo Gabriel Peralta, Sanne Schoffelen, Anders Holmgaard Hansen, Johnny Arnsdorf, Song‐Min Schinn, Jonathan R. Skidmore, Biswa Choudhury, Frances Rocamora, Mousumi Paulchakrabarti, Bjørn Gunnar Rude Voldborg, Austin W.T. Chiang, Nathan E. Lewis

LeGenD predicts N-glycan structures and their abundance using lectin-binding patterns and AI, trained on glycoprofiles from recombinant proteins.

Journal of Biological Chemistry · Jun 4, 2026Peer-reviewedBioengineering

Delineating the Transcriptional and Phenotypic Impact from Biotherapeutic Glycoengineering

Haining Li, Austin W.T. Chiang, Vahid Gazestani, Bokan Bao, Shangzhong Li, P Ménard, Johnny Arnsdorf, Zulfiya Sukhova, Sara Petersen Bjørn, Karen Kathrine Brøndum, Anders Holmgaard Hansen, Sanne Schoffelen, Bjørn Gunnar Rude Voldborg, Nathan E. Lewis

The paper investigates the phenotypic and transcriptional effects of glycoengineering in CHO cells, identifying distinct clusters and molecular mechanisms associated with different glycosyltransferase modifications.

bioRxiv · Apr 22, 2026 · PreprintSynthetic Biology

Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells

Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas, Nicholas Luke Cowie, Alejandro Gómez Toledo, Soo Min Noh, Karen Julie la Cour Karottki, Marianne Decker, Johnny Arnsdorf, Jose Manuel Camacho-Zaragoza, Stefan Kol, Sanne Schoffelen, Nuša Pristovšek, Anders Holmgaard Hansen, Antonio Alarcón Miguez, , Nathan E. Lewis

This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.

Nature Metabolism · Jan 14, 2025Peer-reviewedBioengineering

A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

Isaac Shamie, Sascha H. C. Duttke, Karen Julie la Cour Karottki, Claudia Z. Han, Anders Holmgaard Hansen, Hooman Hefzi, Kai Xiong, Shangzhong Li, Samuel J. Roth, Jenhan Tao, Gyun Min Lee, Christopher K. Glass, Helene Faustrup Kildegaard, Christopher W. Benner, Nathan E. Lewis

The paper revises transcription start site annotations in Chinese hamster genes using experimental data to improve gene engineering and glycosylation in CHO cells.

NAR Genomics and Bioinformatics · Jun 23, 2021Peer-reviewedGenomics