Alejandro Gómez Toledo

A convergent metabolic-kinase signaling axis links Parkinson s disease and multiple system atrophy

This paper identifies shared metabolic and kinase signaling disruptions in Parkinson's disease and multiple system atrophy using patient-derived models and postmortem tissue.

Release of extracellular matrix components after human traumatic brain injury

This study measures sulfated glycosaminoglycan (sGAG) levels in ventricular CSF, blood, and urine of TBI patients to assess extracellular matrix damage and its correlation with injury characteristics.

Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx

The paper analyzes the BBB glycocalyx using multi-omic approaches, revealing unique glycan composition and structural features, and their potential role in neuroinflammation.

Cumulating MS Signal enables polyclonal antibody analysis

This paper introduces a novel MS score framework for analyzing polyclonal antibodies, demonstrating its ability to identify antibody subgroups and predict interactions.

Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells

This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.