Author

Fredrik Karlsson

AstraZeneca (Sweden)ORCID 0000-0003-3373-0934Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Julia LindgreniD· 2 shared Ákos VégváriiD· 1 shared Alexander Georg NickeliD· 1 shared Anders Dahlen· 1 shared Anders LundiniD· 1 shared Andrea DegasperiiD· 1 shared Angela Membrino· 1 shared Anna Baran· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Julia LindgrenORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 9, 2026

Artemis Regulates Homology-Independent Prime Editing (PRINS) for Enhanced Genomic Insertions

Louis C. Dacquay, Oi Kuan Choong, Angela Membrino…·Marcello Maresca

This study identifies Artemis as a regulator of PRINS editing, showing that modulating Artemis improves insertion efficiency and specificity for genomic engineering.

DOI 10.64898/2025.12.08.693005

humanCRISPR screen

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Molecular BiologyNature CommunicationsPeer-reviewedMar 20, 2024

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function

Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga…·Christer Betsholtz

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

15 citations

mousehuman

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