Julia Lindgren

The paper analyzes CRISPR-Cas9 off-target mutations and translocations at single-cell and tissue-specific levels in mice, revealing context-dependent variability in editing outcomes.

This study identifies Artemis as a regulator of PRINS editing, showing that modulating Artemis improves insertion efficiency and specificity for genomic engineering.

This study develops a multi-omics framework to identify biomarkers of inhaled drug-induced lung toxicity using spatial transcriptomics, proteomics, and histopathological data.

This study maps spatial transcriptomes of human and mouse pulmonary fibrosis to identify fibrotic niches and differences in alveolar regeneration.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

This study uses exome data from 24,576 asthma cases and 120,530 controls to identify rare variants associated with asthma risk, revealing novel subgroups and gene effects.