Chronic cholesterol delivery via brain-permeable nanoparticles improves cognitive and motor function and reduces mutant Huntingtin aggregates in HD mice.

26 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 23, 2020

SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington's disease

Giulia Birolini, Gianluca Verlengia, Francesca Talpo…·Marta Valenza

This study shows that delivering SREBP2 to astrocytes in HD mice restores cholesterol biosynthesis and improves disease symptoms.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 13, 2020

Dose-dependent and disease-modifying effects of striatal infusion of cholesterol in Huntington's disease

Giulia Birolini, Marta Valenza, Eleonora Di Paolo…·Elena F. Cattaneo

This study shows that striatal cholesterol infusion prevents cognitive decline and improves motor function in HD mice, with dose-dependent benefits and synaptic recovery.

1 citation

mouseexperimental assay

𝕏 PostBluesky