SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington's disease
Giulia Birolini, Gianluca Verlengia, Francesca Talpo, Claudia Maniezzi, Lorena Zentilin, Mauro Giacca, Paola Conforti, Chiara Cordiglieri, Claudio Caccia, Valerio Leoni, Franco Taroni, Gerardo Rosario Biella, Michele Simonato, Elena F. Cattaneo, Marta Valenza
This study shows that delivering SREBP2 to astrocytes in HD mice restores cholesterol biosynthesis and improves disease symptoms.
bioRxiv · Nov 23, 2020 · PreprintNeuroscience