Markus J. Sommer

TD2 is a new tool for ab initio annotation of protein-coding ORFs in transcripts, showing sensitivity and precision across diverse eukaryotic transcriptomes.

PSAURON assesses protein-coding gene annotations across species using a machine learning model trained on over 1000 genomes, providing scores to identify high-quality annotations and potential spurious proteins.

CHESS 3 improves upon previous versions by using better algorithms and filtering to create a more accurate catalog of human genes and transcripts.

The paper uses 3D protein structures to evaluate human protein isoforms for biological functionality, refining genome annotations.

3D-Beacons provides a federated network to unify access to protein structure data from multiple sources, enabling comparative analysis of models.

Balrog is a universal gene prediction model for prokaryotes that outperforms existing tools without requiring genome-specific training.