Robert H. Dowen

This study shows that the TWK-26/KCNK3 potassium channel and FLR-4 protein kinase work together in C. elegans to regulate nutrient absorption and metabolic homeostasis.

This study identifies PQM-1 as a stress-responsive transcription factor that promotes proteostasis and organismal survival through a secondary wave stress response mechanism.

This study identifies a non-canonical role for Hedgehog signaling in maintaining lipid homeostasis through regulation of mTORC2 in C. elegans and mouse hepatocytes.

This study identifies FBXL-5 as a negative regulator of vitellogenesis and lipid homeostasis in C. elegans, revealing its role in an SCF ubiquitin-ligase complex interacting with mTORC2 signaling.

The paper identifies a signaling network in C. elegans where DRL-1/FLR-4 MAP Kinases and opposing FLR-2/FSHR-1 signaling regulate growth and lipid homeostasis via p38/PMK-1 and PHA-4/FOXA.