Jennifer Ann Wargo

This study shows that intestinal Bacteroides species degrade tryptophan into indoles, which enhance anti-tumor immunity and limit melanoma growth.

This study uses spatial transcriptomics to show that therapy resistance in melanoma is shaped by both intrinsic cell states and the tumor microenvironment, with distinct resistance programs coexisting in tumors and associated with immune signatures.

TARO integrates microbiome and metabolomic data to identify cross-platform associations by leveraging phylogenetic tree structures and structured sparsity.

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.