Catherine G. Triandafillou

Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance

This study uses spatial transcriptomics to show that therapy resistance in melanoma is shaped by both intrinsic cell states and the tumor microenvironment, with distinct resistance programs coexisting in tumors and associated with immune signatures.

Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

The paper maps spatial gene expression and cell type organization in gastruloids, revealing consistent patterns and novel spatial subclusters.

Gastruloid patterning reflects division of labor among biased stem cell clones

The paper shows that stem cell clones in gastruloids exhibit spatial propensities for anterior/posterior fates, leading to spontaneous division of labor during axial organization.

Lineage memory shapes viral resistance barriers in human skin

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

Pervasive, conserved secondary structure in highly charged protein regions

The paper shows that highly charged protein regions often form structured helices, challenging the assumption that they are disordered, and introduces a better classifier for predicting structure in these regions.