Rossana Lazcano

This study compares canine and human peripheral nerve sheath tumors, finding that H3K27me3 loss and H3K27ac gain drive tumor progression in both species.

This study uses spatial transcriptomics to show that therapy resistance in melanoma is shaped by both intrinsic cell states and the tumor microenvironment, with distinct resistance programs coexisting in tumors and associated with immune signatures.

This study shows ATRX loss in sarcomas correlates with poor outcomes and identifies TEAD inhibition as a potential therapy for ATRX-deficient tumors.

This study shows that oxidative phosphorylation (OXPHOS) is critical for melanoma metastasis to the lungs and brain, based on analysis of human patients and mouse models.

The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.