Author

Aagam S. Shah

Cedars-Sinai Medical CenterORCID 0000-0002-3248-3778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Simon KnottiD· 3 shared Hyungsoo KimiD· 2 shared Omid HamidiD· 2 shared Ze’ev A. RonaiiD· 2 shared Alfredo MolinoloiD· 1 shared Alice Y. HoiD· 1 shared Amanda E. Ramer‐TaitiD· 1 shared Andrei Osterman· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Simon KnottORCID

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3 papers

Recent·Most cited

Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth

Ximena Diaz Olea, Kristin A Beede, Gabriel Vasconcelos Pereira, David A. Scott, Christopher J. Petucci, Eric C. Martens, Dmitri Rodionov, Aagam S. Shah, Miguel P Martinez, Hyungsoo Kim, Ashok Kumar Sharma, Anthony Martin, Tongwu Zhang, Mark B. Faries, Omid Hamid, , Ze’ev A. Ronai

This study shows that intestinal Bacteroides species degrade tryptophan into indoles, which enhance anti-tumor immunity and limit melanoma growth.

Cell Reports Medicine · Jul 1, 2026Peer-reviewedCancer Biology

Targeting the translation initiation complex in therapy-resistant and metastatic melanoma

Yongmei Feng, Ximena Diaz-Olea, Xiurong Ke, Mariia Radaeva, Mehdi Amiri, Hyunjeong Joo, Maryam Jafari, Hyungsoo Kim, Aniruddha J. Deshpande, Steven H. Olson, Predrag Jovanović, Yangqi Su, Aagam S. Shah, Ian Pass, Qiyun Deng, , Ze’ev A. Ronai

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

bioRxiv · Nov 20, 2024 · PreprintCancer Biology

Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures

Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, Aagam S. Shah, David Zitser, Andrew Martinez, Gaorav P. Gupta, Alice Y. Ho, Heather L. McArthur, Stephen Lawrence Shiao, Simon Knott

The paper uses single RNA molecule resolution imaging to analyze immunotherapy response in triple negative breast tumors with tertiary lymphoid structures, identifying two tumor types based on immune infiltration and their differential responses to pembrolizumab and radiation therapy.

bioRxiv · Mar 19, 2024 · PreprintGenomics