Federico Zambelli

Transcription controls chromatin-nuclear lamina contacts through distinct Lamin A and LBR tethering mechanisms

This study shows that transcription inhibition rapidly and reversibly rewires chromatin-nuclear lamina contacts through distinct Lamin A and LBR tethering mechanisms.

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

The paper identifies SOX2 and NR2F1 as regulators of gene expression in the early postnatal visual thalamus, showing their shared target genes and regulatory mechanisms.

Pathological PNPase variants with altered RNA binding and degradation activity affect the phenotype of bacterial and human cell models

The paper investigates the effects of four PNPT1 mutations on PNPase function in bacterial and human models, finding that mutation severity does not correlate with catalytic activity.

VINYL: Variant prIoritizatioN bY survivaL analysis

VINYL prioritizes genetic variants using survival analysis, showing higher accuracy and sensitivity than existing methods in clinical studies.

Laniakea: an open solution to provide Galaxy \"on-demand\" instances over heterogeneous cloud infrastructures.

Laniakea provides a cloud-based platform to deploy Galaxy instances on-demand across heterogeneous infrastructures, enabling customizable and scalable bioinformatics workflows.