Abraham G. Beyene

This paper reveals that dopamine release is highly localized to synapse-like structures, challenging the idea that neuromodulators act diffusely.

The paper introduces WHaloCaMP, a near-infrared calcium indicator, and demonstrates its use in imaging calcium responses in various organisms.

This paper introduces a 2D nanofilm to visualize dopamine release with synaptic resolution and quantal sensitivity, revealing spatial patterns and colocalization with Bassoon in dendrites.

This paper develops a near-infrared serotonin nanosensor through synthetic evolution, showing high selectivity and affinity for serotonin over other compounds and enabling reversible imaging in brain slices.

This paper introduces a non-genetically encoded near-infrared fluorescent nanosensor to image dopamine release in brain tissue with high spatial and temporal resolution.

This paper develops an ultrasensitive nanosensor for dopamine and norepinephrine using ssDNA-SWNT conjugates and elucidates the photophysical mechanisms behind its fluorescence modulation.

This paper develops a method for deep-brain neurotransmitter imaging using two-photon excitation of near-infrared nanosensors, showing reduced scattering and improved image quality.

The paper develops a stochastic model of dopamine dynamics in the striatal extracellular space to optimize fluorescent nanosensor design and imaging parameters for in vivo neuromodulation imaging.