Fabio Affaticati

This study compares T cell receptor repertoire diversity and epigenetic clocks to assess healthy aging and CMV impact, finding higher TCR diversity in healthy elderly and CMV-related epigenetic aging.

The paper introduces AIRRWAS, a framework to identify T cell receptor convergence with bacterial genera, revealing reproducible associations across cohorts and functional T cell responses.

The paper links immunotypes and enterotypes through a systems immunology approach, showing they are orthogonal and connected via the blood transcriptome, with associations between specific bacteria and immune health.

This study uses multi-view modelling to improve prediction of HBV vaccine response by integrating bulk RNA-seq, T-cell data, flow cytometry, and clinical metadata.

This study uses interpretable deep learning to analyze TCR-epitope interactions and identify molecular binding patterns that influence TCR affinity.