Christiane Fuchs

The paper analyzes identifiability of parameters in ODE and SDE models of translation kinetics after mRNA transfection, finding that SDE models provide better parameter identifiability.

CLUE is a bioinformatic and wet-lab pipeline that enables the multiplexed generation of custom sgRNA libraries, producing uniform and contamination-free results.

The paper investigates the mechanistic model underlying the negative binomial distribution of single-cell mRNA counts, showing it arises from bursty transcription.

The paper introduces pheno-seq, a method that links morphological features to gene expression in 3D cell cultures, showing its ability to identify morphology-specific genes and regulatory states not captured by scRNA-seq.

This paper presents a crowdsourced challenge to predict early discontinuation of docetaxel in mCRPC patients using clinical data from multiple trials, finding that ensemble models outperform individual models.