pheno-seq - linking morphological features to gene expression in 3D cell culture systems
Stephan M. Tirier, Jeongbin Park, Friedrich Preußer, Lisa Amrhein, Zuguang Gu, Simon Steiger, Jan‐Philipp Mallm, Marcel Waschow, Björn Eismann, Marta Gut, Ivo Glynne Gut, Karsten Rippe, Matthias Schlesner, Fabian Joachim Theis, Christiane Fuchs, , Christian Conrad
The paper introduces pheno-seq, a method that links morphological features to gene expression in 3D cell cultures, showing its ability to identify morphology-specific genes and regulatory states not captured by scRNA-seq.
bioRxiv · Sep 12, 2018 · PreprintGenomics