Author

Bingbing Duan

University of PittsburghORCID 0000-0003-3645-0700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:yeast· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Chenxi QiuiD· 2 shared Craig D. KaplaniD· 2 shared Sing‐Hoi SzeiD· 2 shared Steve W. LocklessiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Chenxi QiuORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

GeneticsNature CommunicationsPeer-reviewedAug 27, 2025

Widespread epistasis shapes RNA Polymerase II active site function and evolution

Bingbing Duan, Chenxi Qiu, Sing‐Hoi Sze, Craig D. Kaplan

The paper uses deep mutational scanning in yeast to analyze residue interactions in the RNA Polymerase II trigger loop, revealing its functional and evolutionary constraints.

5 citations

yeastexperimental assay

𝕏 PostBluesky

GeneticsGeneticsPeer-reviewedOct 24, 2024

Higher-order epistasis within Pol II trigger loop haplotypes

Bingbing Duan, Chenxi Qiu, Steve W. Lockless…·Craig D. Kaplan

The paper investigates higher-order epistasis within Pol II trigger loop haplotypes, identifying complex genetic interactions that influence Pol II function and evolution.

1 citation

yeaststatistical model

𝕏 PostBluesky