Sing‐Hoi Sze

The paper uses deep mutational scanning in yeast to analyze residue interactions in the RNA Polymerase II trigger loop, revealing its functional and evolutionary constraints.

The paper investigates higher-order epistasis within Pol II trigger loop haplotypes, identifying complex genetic interactions that influence Pol II function and evolution.

The paper quantitatively analyzes TSS selection in yeast using a new assay, showing sequence, Pol II activity, and NTP levels influence initiation efficiency.

The paper investigates promoter scanning by Pol II in yeast, showing that it occurs across all promoters and is influenced by Pol II activity and promoter architecture.

This study provides insights into the biology of the stable fly by combining genome sequencing, microbiome analysis, and RNA-seq to identify genes related to reproduction, host interactions, and pest control.