Chenxi Qiu

This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.

The paper uses deep mutational scanning in yeast to analyze residue interactions in the RNA Polymerase II trigger loop, revealing its functional and evolutionary constraints.

The paper investigates higher-order epistasis within Pol II trigger loop haplotypes, identifying complex genetic interactions that influence Pol II function and evolution.

This study investigates thiolutin's mode of action, showing it directly inhibits RNA Polymerase II in vitro but has complex in vivo effects involving oxidative stress and metal interactions.

The paper investigates promoter scanning by Pol II in yeast, showing that it occurs across all promoters and is influenced by Pol II activity and promoter architecture.

The paper investigates the effects of altered Pol II catalytic activity on gene expression in yeast, finding unexpected results regarding elongation rates and mRNA stability.

The paper quantitatively phenotypes nearly all single-residue variants of the RNA Polymerase II trigger loop in Saccharomyces cerevisiae to uncover functional classes and their roles in transcription.