Arnaud Ogier

The paper develops an imaging and analysis framework to map human microglial activation states using handcrafted and deep learning features, showing deep learning features achieve high classification accuracy and correlate with biological states.

The paper identifies compounds that restore morphology in Parkinson's disease neurons by targeting mitochondrial uncoupling.

The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

The paper uses machine learning to classify Parkinson's disease patient-derived midbrain dopaminergic neurons based on multiple image-based phenotypes and identifies treatable targets.