Patricia A. Clow

This study investigates cohesin's role in transcriptional loops and DNA replication using human cells, finding that cohesin loss affects long-range chromatin interactions and up-regulates early initiation zone genes.

This paper presents a xeno-free protocol to rapidly differentiate human iPSCs into microglia using the KOLF2.1J line, resulting in functional microglia with immune markers and phagocytic activity.

This study shows ecDNA forms nuclear condensates and reorganizes chromatin to enhance oncogenic transcription across cancer types.

This paper introduces a CRISPR-based imaging method to label nonrepetitive genomic loci and track chromatin dynamics in live cells.