Albert W. Cheng

This study investigates cohesin's role in transcriptional loops and DNA replication using human cells, finding that cohesin loss affects long-range chromatin interactions and up-regulates early initiation zone genes.

This paper introduces an interpretable online dictionary learning method for analyzing long-range chromatin interactions in Drosophila using ChIA-Drop data.

This study evaluates RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce mis-spliced ABCA4 variants in Stargardt disease, showing significant reductions in disease-causing splice variants.

The paper introduces an algorithm to infer chromatin interaction patterns from ChIA-Drop data and demonstrates its ability to reconstruct interaction networks and identify functional chromatin elements.

JACKIE enumerates genomic single- and multi-copy target sites and their off-targets for CRISPR and other nucleases, enabling efficient design and visualization.

This paper introduces a CRISPR-based imaging method to label nonrepetitive genomic loci and track chromatin dynamics in live cells.

The paper evaluates DNA methylation calling tools for Oxford Nanopore sequencing using human data and provides an online database for comparing tool performance.

Casilio-ME enhances CRISPR-based DNA demethylation by coupling TET1 with DNA repair factors to activate methylation-silenced genes.