Author

Aziz Taghbalout

The Jackson Laboratory for Genomic MedicineORCID 0000-0002-6767-0258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Albert W. ChengiD· 3 shared Nathaniel JilletteiD· 3 shared Menghan Du· 2 shared Patricia A. ClowiD· 2 shared Sheng LiiD· 2 shared Wojciech RosikiewicziD· 2 shared Abhijit RathiD· 1 shared Albert H. KimiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Albert W. ChengORCID

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Author profile →

4 papers

Recent·Most cited

Extrachromosomal DNA Associates with Nuclear Condensates and Reorganizes Chromatin Structures to Enhance Oncogenic Transcription

Aziz Taghbalout, Chia-Hao Tung, Patricia A. Clow, Harianto Tjong, Ping Wang, Chee‐Hong Wong, Diane D. Mao, Rahul Maurya, Meng‐Fan Huang, Chew Yee Ngan, Albert H. Kim, Chia‐Lin Wei

This study shows ecDNA forms nuclear condensates and reorganizes chromatin to enhance oncogenic transcription across cancer types.

Cancer Cell · Sep 23, 2025Peer-reviewedGenomics

CRISPR-mediated Multiplexed Live Cell Imaging of Nonrepetitive Genomic Loci

Patricia A. Clow, Menghan Du, Nathaniel Jillette, Aziz Taghbalout, Jacqueline Jufen Zhu, Albert W. Cheng

This paper introduces a CRISPR-based imaging method to label nonrepetitive genomic loci and track chromatin dynamics in live cells.

Nature Communications · Apr 6, 2022Peer-reviewedGenomics

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation

Yang Liu, Wojciech Rosikiewicz, Ziwei Pan, Nathaniel Jillette, Ping Wang, Aziz Taghbalout, Jonathan Foox, Christopher E. Mason, Martin P Carroll, Albert W. Cheng, Sheng Li

The paper evaluates DNA methylation calling tools for Oxford Nanopore sequencing using human data and provides an online database for comparing tool performance.

Genome biology · Oct 18, 2021Peer-reviewedBioinformatics

Casilio-ME: Enhanced CRISPR-based DNA demethylation by RNA-guided coupling methylcytosine oxidation and DNA repair pathways

Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng

Casilio-ME enhances CRISPR-based DNA demethylation by coupling TET1 with DNA repair factors to activate methylation-silenced genes.

Nature Communications · Sep 20, 2019Peer-reviewedGenomics