Anja Groth

CREPAS is a Nextflow pipeline for analyzing nascent chromatin sequencing data, improving scalability, reproducibility, and compatibility across multiple chromatin assays.

This study shows that FACT depletion in stem cells causes a sequence of chromatin disruptions leading to transcriptional collapse.

This study shows that FACT is essential for chromatin replication and transcription by disrupting and reassembling nucleosomes, preventing genome aggregation.

This study uses a ubiquitin replacement strategy to show K29-linked ubiquitylation regulates SUV39H1 stability and H3K9me3 levels in human cells.

This study determines the structure of the CODANIN-1_ASF1 complex, revealing how CODANIN-1 inhibits ASF1-mediated histone supply by sequestering ASF1 in the cytoplasm.

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.

The paper models the propagation and stability of K27 and K36 methylation landscapes using computational methods and mass spectrometry data.