Rodrigo Mohallem

This study links phosphoproteome modifications to cortical circuit dysfunction in early-stage alpha-synuclein aggregation using multi-omics analysis in rat and mouse models.

The paper investigates how phosphorylation near the pT181 epitope affects the affinity of pT181-tau antibodies, finding that phosphorylation at S184 or S185 can completely eliminate antibody binding.

The paper uses a multi-omics approach to analyze proteomic, phosphoproteomic, and lipidomic data from mouse livers to identify dysregulated protein phosphorylation and lipid metabolism in diet-induced obesity.

This study uses quantitative proteomics to identify regulators of TNFα-mediated insulin resistance in adipocytes under chronic inflammation.