Mechanisms of Alpha-Synuclein Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging
Paula-Marie E. Ivey, Magaly Guzman Sosa, Abdelrahman M. Salem, Sehong Min, Wenzhu Qi, Alicia N. Scott, Karin F.K. Ejendal, Tamara L. Kinzer‐Ursem, Jean‐Christophe Rochet, Kevin John Webb
This study uses fluorescence lifetime imaging to track alpha-synuclein aggregation in neurons, revealing that seeds disassemble before escaping endolysosomes and triggering cytosolic aggregation.
ACS Chemical Neuroscience · May 27, 2025Peer-reviewedNeuroscience