Jack L. Feldman

This study shows high-dose CBD pretreatment reduces opioid-induced persistent apnea in mice, as effective as naloxone, suggesting a new approach to prevent opioid overdose deaths.

This study shows that slow breathing in mice reduces stress-related behaviors, suggesting a direct neural mechanism rather than top-down control.

The paper investigates neural mechanisms of sigh generation, showing that preBotC SST neurons can induce sighs independently of NMBR and GRPR pathways.

This paper investigates how preBotC SST+ neurons modulate breathing patterns in different states and frequencies, revealing phase- and state-dependent responses that challenge existing models.

The paper uses computational models to show that directed Erdős-Rényi graphs and lognormal synaptic weights in the preBötzinger Complex generate robust breathing rhythms through synchronization and input convergence.

This study identifies monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons from brainstem and suprapontine regions using rabies tracing.

The paper investigates preBotC network dynamics under rhythmic and nonrhythmic conditions, revealing synchronization mechanisms and their role in respiratory rhythmogenesis.

The paper investigates how respiratory rhythm is generated in the preBotzinger Complex and shows that opioid receptors modulate burstlet frequency, independent of motor output bursts.