Clemens Cabernard

CrisprBuildr is a web-based tool for designing CRISPR constructs in Drosophila to delete genes or insert fluorescent tags, streamlining genome engineering workflows.

The paper investigates how altering cell size asymmetry in Drosophila neural stem cells affects their proliferation and lineage potential, finding increased stem cell pools but reduced lineage size and differentiation.

The paper shows asymmetric centromere positioning in Drosophila neural stem cells, linked to microtubules and specific proteins, and correlates with gene locus positioning.

This study shows that Protein phosphatase 4 (Pp4) is required for centrosome asymmetry in fly neural stem cells by regulating the relocalization of Centrobin and maintaining MTOC activity.

The paper develops engineered kinases to specifically phosphorylate fluorescent protein fusions in vivo, demonstrating their use in studying actomyosin activation in Drosophila embryos.

This study shows that Drosophila scrib mutant tumors transition from a growth arrest to a proliferative state over time, suggesting potential for tumor evolution.