Mengxue Tian

PATTY corrects open chromatin bias in CUT&Tag data using ATAC-seq and machine learning, improving detection of histone modifications and cell clustering in single-cell analyses.

This study investigates the role of ORC2 in epigenetic regulation and chromosome structure through a multi-omics analysis of a human cell line with ORC mutations.

The paper analyzes DNA replication origins and ORC/MCM binding sites in human cells, finding minimal overlap and suggesting origins are specified by stochastic events rather than specific binding sites.