Yoshiyuki Shibata

The paper identifies tRF-3021a as a cancer-promoting tRNA-derived fragment that supports invasiveness, apoptosis resistance, and global protein synthesis in cancer cell lines.

This study investigates the role of ORC2 in epigenetic regulation and chromosome structure through a multi-omics analysis of a human cell line with ORC mutations.

The paper shows that specific DNA replication origins are still used and excess MCM2-7 is loaded in ORC-deficient human cancer cells.

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

The paper analyzes DNA replication origins and ORC/MCM binding sites in human cells, finding minimal overlap and suggesting origins are specified by stochastic events rather than specific binding sites.

The paper shows that ATAC-seq can detect thousands of extrachromosomal circular DNAs in cancer and cell lines without specific enrichment.

The paper shows that microDNA produces regulatory RNAs that suppress gene expression through miRNA and si-like RNA mechanisms.