Jiawen Du

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

This study identifies 62 Alzheimer's disease-associated genes using retinal transcriptome-wide association studies and validates 31 in an independent cohort, highlighting immune dysregulation and novel risk genes.

PEARL is a deep graph learning method for multi-omics integration that outperforms existing methods and identifies functionally important genes in Alzheimer's disease.

MuSHIN improves genome-scale metabolic models by predicting missing reactions using a deep hypergraph learning method, enhancing their predictive accuracy and phenotypic predictions.

The paper improves risk prediction for cardiometabolic traits in American Indians by integrating polygenic scores with lifestyle and clinical context variables, enhancing model discrimination for coronary heart disease.

This study identifies twelve novel blood pressure loci and shows smoking modifies genetic effects on BP through immune-related pathways in over 1 million individuals.

DREAM-GNN improves drug repositioning by integrating heterogeneous biomedical data through a dual-route graph neural network framework, outperforming existing methods in recovering repositioning candidates.

This study identifies 22 novel gene-sleep duration interaction loci for blood pressure traits across 811,405 individuals, highlighting distinct genetic influences of short and long sleep on cardiovascular health.