Anna O’Donnell

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

This study identifies the versican-hyaluronan complex as essential for vasculogenesis and primitive hematopoiesis by providing a niche for Flk1+ progenitors during gastrulation.

The paper identifies differential proteoglycan dynamics in umbilical artery and vein as the mechanism ensuring rapid arterial closure and venous patency at birth.