R. Sathish Srinivasan

A GATA2-PROX1-FOXC2 regulatory axis integrates shear stress signaling with lymphatic vascular development

The paper identifies a GATA2-PROX1-FOXC2 regulatory axis that integrates shear stress signaling with lymphatic vascular development, showing dosage-dependent cooperation between GATA2 and FOXC2.

Development and Function of Ovarian Lymphatic Vasculature

This study investigates the development and function of the ovarian lymphatic vasculature in mice, revealing its origin and the role of VEGF-C/VEGFR-3 signaling in preventing fibrosis and ovarian aging.

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ Formation

This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.

PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

This study identifies S1PR1 as a regulator of lymphatic vessel quiescence by inhibiting LSS-dependent VEGF-C signaling in lymphatic endothelial cells.

RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice

This study shows that RASA1 is required for the development of lymphovenous and venous valves by regulating collagen IV export from endothelial cells in mice.

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

This study identifies GATA2's role in maintaining lymphatic endothelial cell junctions and valve morphogenesis through regulation of miR-126.