Atishay Jay

The paper shows lineage-determining transcription factors position enhancers and promoters to enable multi-enhancer regulation of oncogenes in lymphoma and T-cell leukemia.

OLIVE provides a web-based tool for visualizing and analyzing chromatin tracing data, enabling interactive exploration and quantitative analysis of three-dimensional chromatin structures.

The paper uses single-allele chromatin tracing to show that genomic clustering of paralogous transcription factors enables developmental robustness in T cells by allowing compensatory interactions when regulatory elements are lost.