Sora Yoon

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation

The paper shows lineage-determining transcription factors position enhancers and promoters to enable multi-enhancer regulation of oncogenes in lymphoma and T-cell leukemia.

Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety

Hi-Cociety infers 3D enhancer communities from Hi-C data in T lymphocytes, identifying key regulatory modules and cell-type-specific chromatin organization differences.

Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells

The paper uses single-allele chromatin tracing to show that genomic clustering of paralogous transcription factors enables developmental robustness in T cells by allowing compensatory interactions when regulatory elements are lost.

High-throughput Oligopaint screen identifies druggable regulators of genome folding

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

Stripenn detects architectural stripes from chromatin conformation data using computer vision

Stripenn detects and quantifies architectural stripes from chromatin conformation data using computer vision, outperforming existing methods in biological applications.