Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation
Yeqiao Zhou, Atishay Jay, Noah G. Burget, Tobias Friedrich, Sora Yoon, Jessica Alsing, Guy Nir, Rudolf Grosschedl, Golnaz Vahedi, Robert B. Faryabi
The paper shows lineage-determining transcription factors position enhancers and promoters to enable multi-enhancer regulation of oncogenes in lymphoma and T-cell leukemia.
Nature Cell Biology · Dec 2, 2025Peer-reviewedCancer Biology