Mark A. Dane

This study identifies SASP factors that drive tumorigenesis in breast and lung cancer cells using a microarray platform and validates their role in growth and survival.

This study identifies HIF1A as a key mediator of OSM-induced collective epithelial migration, linking cytokine signaling to metabolic and immune pathways in breast cancer.

This study identifies SNO-COX-2 as a biomarker for mesenchymal phenotypes in breast cancer, showing its microenvironmental regulation and association with invasive growth.

This study shows paclitaxel response in TNBC mimics interferon response, revealing ELF3 as a biomarker for resistance.

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

The paper develops a method to remove technical artifacts from high-throughput imaging assays using systematic replication, improving biological signal clarity.

The paper introduces ME-VAE, a multi-encoder VAE for single-cell image analysis that extracts transform-invariant biologically meaningful features, improving cell population separation and phenotypic differences.

The paper investigates how nutrient limitations affect invasion in cancer populations, showing that phenotypic imbalance accelerates invasion while balance decelerates it.

The paper investigates how preprocessing transformations improve the discovery of biological and technical effects in microenvironment microarray data.