Alejandra Bosco

This study shows Klf4 overexpression reprograms late retinal progenitor cells to adopt a retinal ganglion cell-like identity through transcriptional and epigenetic changes.

This study shows that overexpressing Pou4f2 in late retinal progenitors generates RGC-like neurons with axonal projections to brain regions.

The paper identifies CD11c-expressing microglia as a transient state in the developing retina driven by interactions with apoptotic cells, not a specialized subset for phagocytic clearance.

The paper investigates how interactions with apoptotic neurons influence microglial states and survival pathway dependence using scRNAseq in mouse retina.

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.