Sarah Anderson

CD11c-expressing microglia are transient, driven by interactions with apoptotic cells

The paper identifies CD11c-expressing microglia as a transient state in the developing retina driven by interactions with apoptotic cells, not a specialized subset for phagocytic clearance.

Microglial cathepsin B promotes neuronal efferocytosis during brain development

This study shows that microglial cathepsin B is essential for efficient neuronal efferocytosis during brain development, preventing apoptotic cell accumulation and ensuring proper neural circuit formation.

Type I interferon responsive microglia shape cortical development and behavior

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.