Fabio Mammano

This study engineers oncolytic HSV-1 viruses with photosensitizing and immunotherapeutic properties to treat glioblastoma in preclinical models.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

The paper shows that immature inner hair cells in the cochlea have intrinsic Ca2+ action potentials that are bidirectionally coupled to ATP-dependent Ca2+ signaling in non-sensory cells.

The paper shows that spontaneous Ca2+ signals from OHCs and non-sensory cells coordinate to refine OHC afferent innervation during development.