Miloslav Sedlacek

Spontaneous calcium transients in hair cell stereocilia

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa

The paper tests a drug to reduce noise in retinal circuits of mice with retinitis pigmentosa, finding it preserves visual sensitivity while decreasing circuit noise.

Dendro-somatic synaptic inputs to ganglion cells violate receptive field and connectivity rules in the mammalian retina

The paper identifies a retinal circuit where A2 amacrine cells inhibit OFF ganglion cells in the ON layer, contradicting established connectivity and receptive field rules.

Dynamic coupling of cochlear inner hair cell intrinsic Ca2+ action potentials to Ca2+ signaling of non-sensory cells

The paper shows that immature inner hair cells in the cochlea have intrinsic Ca2+ action potentials that are bidirectionally coupled to ATP-dependent Ca2+ signaling in non-sensory cells.