Author

Sven Heiles

Leibniz Institute for Analytical Sciences - ISASORCID 0000-0003-3779-8071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Organism:human· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Elen TolstikiD· 2 shared Felix-Levin HormanniD· 2 shared Johann Dierks· 2 shared Kristina LorenziD· 2 shared Adolfo SaiardiiD· 1 shared Albert SickmanniD· 1 shared Alpaslan TasdoganiD· 1 shared Andreas HentscheliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Elen TolstikORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 21, 2026

SIMO - Single Section Integrative Multi-Omics - spatial mapping of metabolites and lipids combined with region-specific proteomics in a single tissue slice

Kevin Hau, Antonia Fecke, Felix-Levin Hormann…·Karl W. Smith

SIMO integrates spatial metabolomics, lipidomics, and proteomics from a single tissue section to enable comprehensive multi-omics analysis across spatial regions.

DOI 10.64898/2026.04.17.719206

mousemetabolomics

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BiochemistrybioRxivPreprintApr 9, 2026

Isotopic tracing of scyllo-inositol uncovers its incorporation into phosphatidylinositols in mammalian cells

M. K. P. Amma, Laxmikanth Kollipara, Peter Schmieder…·Dorothea Fiedler

This paper develops [13C6]scyllo-inositol as an isotopic tracer to study its metabolism and shows its incorporation into phosphatidylinositols in mammalian cells.

DOI 10.64898/2026.04.07.716873

humanmetabolomics

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Molecular BiologybioRxivPreprintNov 27, 2025

Automatic colocalization of high resolution MALDI MSI and Raman imaging applied to cardiac tissue of Fabry disease mouse models

Johann Dierks, Eike Ulrich Brockmann, Paula-Anahi Arias-Loza…·Sven Heiles

The paper develops a multimodal imaging approach combining Raman and AP-MALDI MSI to detect Gb3 accumulation in cardiac tissue of Fabry disease mouse models.

DOI 10.1101/2025.11.27.690907

mouseimaging

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PathologyNature CommunicationsPeer-reviewedApr 26, 2025

Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction

Marion Müller, Torben Schubert, Cornelius Welke…·Anna Klinke

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

14 citationstop 2%

mouseproteomics

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